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RegisterFunction CVpooled (package PowerTOST) [🇷 for BE/BA]
Hi all,
can we take one step back and ask which question the pooled CV provides an answer to?
"If the CV across all studies happens to be the same, then which CV is most likely representing all the studies?"
[yes, add alfalfa and limits if you wish]
Now, I hate to say it, but boring things like blood sampling regimen, analytical setups, stats model, within-batch variation of both T and R, volunteer constraints postdose, and other factors will influence directly on a CV. If you are in doubt, look at the list provided in this thread.
Please give me a good reason to believe all those factors (plus all the ones I forgot) are the same across just any two studies. You pick and show me. Until then I consider pooled CV's a curiosity as useful as headmounted toilet paper etc.
A cheeseburger is pretty well assumed to be the same regardless of whether you buy it at McDonald's in Pasadena, Paris or Peking. A cheeseburger is a cheeseburger is a cheeseburger. Until we bring Burger King into the picture. Or Hardee's. Or...
This pooled business is not the way forward, gentlemen and gentlewomen. But it is highly theoretically and academically appealing, I grant you all that.
Now if you will excuse me I must end this post here as I have to blow my nose. I am sure I put that roll of toilet paper somewhere, but I just can't seem to find it right now... Bloody hell...
can we take one step back and ask which question the pooled CV provides an answer to?
"If the CV across all studies happens to be the same, then which CV is most likely representing all the studies?"
[yes, add alfalfa and limits if you wish]
Now, I hate to say it, but boring things like blood sampling regimen, analytical setups, stats model, within-batch variation of both T and R, volunteer constraints postdose, and other factors will influence directly on a CV. If you are in doubt, look at the list provided in this thread.
Please give me a good reason to believe all those factors (plus all the ones I forgot) are the same across just any two studies. You pick and show me. Until then I consider pooled CV's a curiosity as useful as headmounted toilet paper etc.
A cheeseburger is pretty well assumed to be the same regardless of whether you buy it at McDonald's in Pasadena, Paris or Peking. A cheeseburger is a cheeseburger is a cheeseburger. Until we bring Burger King into the picture. Or Hardee's. Or...
This pooled business is not the way forward, gentlemen and gentlewomen. But it is highly theoretically and academically appealing, I grant you all that.
Now if you will excuse me I must end this post here as I have to blow my nose. I am sure I put that roll of toilet paper somewhere, but I just can't seem to find it right now... Bloody hell...
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Function CVpooled (package PowerTOST) Elena777 2018-01-21 08:53 [🇷 for BE/BA]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Function CVpooled (lengthy answer) Helmut 2018-01-21 17:21
- Function CVpooled (lengthy answer) Elena777 2018-01-27 10:11
- Function CVpooled (package PowerTOST)ElMaestro 2018-01-27 22:28
- Common sense Helmut 2018-01-28 00:27
- Common sense ElMaestro 2018-01-28 08:43
- Alzheimer’s Helmut 2018-01-28 11:38
- Common sense ElMaestro 2018-01-28 08:43
- To pool or not to pool d_labes 2018-01-28 13:52
- Common sense Helmut 2018-01-28 00:27
- Function CVpooled (package PowerTOST) ElMaestro 2018-01-29 00:07
- Pooling is fooling? Helmut 2018-01-29 17:53
- Pooling is fooling? nobody 2018-01-29 19:21
- Life is good ElMaestro 2018-01-30 18:23
- Life is good nobody 2018-01-30 18:31
- Life is good ElMaestro 2018-01-30 18:23
- Pooling is fooling? nobody 2018-01-29 19:21
- Pooling is fooling? Helmut 2018-01-29 17:53
- Function CVpooled (lengthy answer) Helmut 2018-01-21 17:21
Ing. Helmut Schütz
