Bioequivalence and Bioavailability Forum

❝ […] In partial replicate designs (TRR|RTR|RRT) I suggest to specify two analysis sets if data of the third period in sequence RRT is missing:

1. Exclude subjects from the assessment of BE since the GL requires at least one treatment of T and R.
   

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2. Keep subjects for the estimation of CV_wR.

Yes

❝ ❝ I want a clarified answer please with guideline reference if applicable.

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❝ The Q&A document …

Thanks for the link

❝ From a purely statistical perspective my preferences are: Method C ≫ Method B > Method A. I don’t like the idea to treat subjects as a fixed effect.

That's what I believe too
Check this link: doi:10.12793/tcp.2014.22.2.78

❝ Given the observations from above, a sponsor probably would fair best with Method A only.

Of course

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Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! doi corrected. [Helmut]