## Simulations [Power / Sample Size]

» Is it worth to calculate sample size at power of 95%?
» Are there any risks?

Too many subjects
It is unethical to disturb more subjects than necessary
Some subjects at risk and they are not necessary
It is an unnecessary waste of some resources ($) It takes more time to analytical sample analysis - time is money <- this does not a apply to a rich client Too few subjects A study unable to reach its objective is unethical All subjects at risk for nothing All resources ($) is wasted when the study is inconclusive