Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

Back to the forum  2018-07-20 19:02 CEST (UTC+2h)

Imbalanced randomization sequence before conducting the study [Design Issues]

posted by Mohamed Yehia - Egypt, 2018-01-11 16:19  - Posting: # 18168
Views: 858

Hi All,

Is it possible to make imbalanced Randomization sequence before entering the study?

For example, using 33 subjects for 2 treatment, 2 sequence, 4 period cross over study.

In my opinion, I don't accept this as despite the fact of the possibility of getting imbalanced sequence as a result of subject withdrawal, but I think that this does not mean that it is acceptable to perform imbalanced randomization from the beginning.

I want your opinion asap.

Thanks


Edit: Relax; see also this post #9. [Helmut]

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
18,547 posts in 3,941 threads, 1,191 registered users;
online 20 (1 registered, 19 guests [including 10 identified bots]).

If there is an exception to any rule,
and if it can be proved by observation,
that rule is wrong.    Richard Feynman

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed