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Back to the forum  Query: 2018-01-22 21:21 CET (UTC+1h)
 

Imbalanced randomization sequence before conducting the study [Design Issues]

posted by Mohamed Yehia - Egypt, 2018-01-11 16:19  - Posting: # 18168
Views: 281

Hi All,

Is it possible to make imbalanced Randomization sequence before entering the study?

For example, using 33 subjects for 2 treatment, 2 sequence, 4 period cross over study.

In my opinion, I don't accept this as despite the fact of the possibility of getting imbalanced sequence as a result of subject withdrawal, but I think that this does not mean that it is acceptable to perform imbalanced randomization from the beginning.

I want your opinion asap.

Thanks


Edit: Relax; see also this post #9. [Helmut]

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