Distinguish accumulation [NCA / SHAM]

posted by oksanachlebko – Ukraine, 2018-01-05 00:10  – Posting: # 18146
Views: 4,567

Dear Helmut!
I kindly ask you to help me with the following question!

» If I get an accumulation index in the MD study more or less different from 1 I try to give additional information, whether the drug shows true nonlinear PK, or only a small shift due to the second compartment.

is it possible to distinguish true nonlinear PK and shift due to other compartments?
What if the dose proportionality is proven but accumulation index is more than 1.4?

All the Best!
Oksana

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