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RegisterDistinguish accumulation [NCA / SHAM]
Dear Helmut!
I kindly ask you to help me with the following question!
» If I get an accumulation index in the MD study more or less different from 1 I try to give additional information, whether the drug shows true nonlinear PK, or only a small shift due to the second compartment.
is it possible to distinguish true nonlinear PK and shift due to other compartments?
What if the dose proportionality is proven but accumulation index is more than 1.4?
All the Best!
Oksana
I kindly ask you to help me with the following question!
» If I get an accumulation index in the MD study more or less different from 1 I try to give additional information, whether the drug shows true nonlinear PK, or only a small shift due to the second compartment.
is it possible to distinguish true nonlinear PK and shift due to other compartments?
What if the dose proportionality is proven but accumulation index is more than 1.4?
All the Best!
Oksana
Complete thread:
- half-life in multiple-dosed steady-state BE/BA study? yjlee168 2009-07-14 14:16
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- half-life in steady state; WinNonlin Helmut 2009-07-15 15:09
- no lambda(z), no NCA? yjlee168 2009-07-16 11:53
- NCA without lambda(z) Helmut 2009-07-16 14:06
- No rule is the rule - lambda(z) of MD BE yjlee168 2009-07-16 22:17
- NCA without lambda(z) Helmut 2009-07-16 14:06
- Distinguish accumulationoksanachlebko 2018-01-05 00:10
- no lambda(z), no NCA? yjlee168 2009-07-16 11:53
- half-life in steady state; WinNonlin Helmut 2009-07-15 15:09
Ing. Helmut Schütz