Bioequivalence and Bioavailability Forum

Precision of PowerTOST [Power / Sample Size]

posted by Astea – Russia, 2017-12-10 01:10 (2762 d 12:10 ago) – Posting: # 18051
Views: 15,456

Dear All!

Thank you for clarifying this question! Interesting consequences!

How much time did you spend on plotting with 1E6 reps? My comp hanged over when I tried to get more than 1E4...

❝ So the answer is: yes, that's possible, but you need to be unlucky (the probability is about 7%)

For 72 subjects and theta0=0.9 we get even worser: 98.21 are less than 0.8 (checked with 10⁴ reps).

Complete thread:

• Sample Size Estimation -Replicate design- BE limits cakhatri 2017-11-30 09:44 [Power / Sample Size] 
  • Reference-scaling: Don’t use FARTSSIE! Helmut 2017-11-30 10:58
    • Reference-scaling: Don’t use FARTSSIE? Astea 2017-11-30 22:50
      • Reference-scaling: Don’t use FARTSSIE! Helmut 2017-12-01 11:42
        • Reference-scaling: USE PowerTOST Astea 2017-12-01 14:16
          • Reference-scaling: USE PowerTOST cakhatri 2017-12-04 06:00
            • Reference-scaling: USE PowerTOST Helmut 2017-12-04 15:07
              • Reference-scaling: USE PowerTOST cakhatri 2017-12-05 05:33
          • Use PowerTOST d_labes 2017-12-06 09:52
            • Use PowerTOST, not Endrényi L, Tóthfalusi L tables mittyri 2017-12-07 16:03
              • Precision in Endrényi L, Tóthfalusi L tables d_labes 2017-12-07 18:21
                • Precision of PowerTOST mittyri 2017-12-08 22:56
                  • Precision of PowerTOST Helmut 2017-12-09 17:00
                    • Precision of PowerTOST mittyri 2017-12-09 21:05
                      • Precision of PowerTOSTAstea 2017-12-10 00:10
                        • Precision of PowerTOST Helmut 2017-12-10 20:27
                          • Precision of PowerTOST Astea 2017-12-10 21:13
    • Reference-scaling: Don’t use FARTSSIE! pjs 2018-02-09 13:08
      • Reference-scaling: Don’t use FARTSSIE! Helmut 2018-02-09 20:15