PK parameters from multiple doses [PK / PD]

posted by nobody – 2017-11-24 15:07  – Posting: # 18001
Views: 5,984

» I would echo Helmut's comments regarding the assumptions you would have to make and convey to your audience; probably I would try to build a compartmental PK model and then simulate a profile for Day 1.

If you built a model based on sampling on Day 15 only, you also have to assume linear PK/no induction. So why not simply use Cl = dose/AUC instead? :-)

Kindest regards, nobody

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