PK parameters from multiple doses [PK / PD]

posted by Yura – Belarus, 2017-11-21 11:48 (1032 d 03:32 ago) – Posting: # 17997
Views: 7,302

Hi Helmut
AUC is truncated with an interval of reception (in the morning and in the evening - 12 hours).
what 24 hours? if after the first dose - it is also 12 hours. Perhaps, the AUCt / AUCi criterion will be less than 80%.
Thank you

Complete thread:

 Admin contact
21,068 posts in 4,392 threads, 1,463 registered users;
online 17 (0 registered, 17 guests [including 12 identified bots]).
Forum time: Friday 16:21 CEST (Europe/Vienna)

The great enemy of the truth is very often not the lie–
deliberate, contrived and dishonest—but the myth—
persistent, persuasive and unrealistic.    John F. Kennedy

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz