Single PK parameters from multiple PK parameters [PK / PD]

posted by asjrm – UK, 2017-11-19 00:44  – Posting: # 17988
Views: 6,770

I am conducting a PK study where multiple doses are given morning and night for 14 days and blood concentrations are measured at pre-dose, 0.5,1,2,3,6,12,24 hours on day 15. The last dose is given on day 15 morning.
The researcher wants me to estimate the PK parameters of the single dose from the blood concentrations of multiple dosing.
is this possible?

Thank you in advance.

Edit: Category changed; see also this post #1. [Helmut]

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