A place to start? [Two-Stage / GS Designs]

posted by d_labes  – Berlin, Germany, 2017-11-13 16:02  – Posting: # 17974
Views: 4,009

Dear ElMaestro,

» can you run a series of sims where you include "20 more subjects than necessary" in stage 2 where a stage 2 is called for?

that could indeed be done within the (in)famous package Power2Stage, function power.2stage.fC() using the argument n2.min. At least partially because n2.min assures a minimum sample size for stage 2, if stage 2 is called for and the estimated sample size is smaller than n2.min.

But that's not the problem Helmut has described, at least as I understand it. Here we initiate a stage 2 from the perspective of the AUC evaluation where it is not neccessary to initiate one.

If having more than necessary number of subjects is a problem at all? My gut feeling says no.

Regards,

Detlew

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,289 posts in 4,100 threads, 1,317 registered users;
online 9 (2 registered, 7 guests [including 7 identified bots]).

A refund for defective software might be nice,
except it would bankrupt the entire software industry
in the first year.    Andrew S. Tanenbaum

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5