A place to start? [Two-Stage / GS Designs]
Dear ElMaestro,
that could indeed be done within the (in)famous package
But that's not the problem Helmut has described, at least as I understand it. Here we initiate a stage 2 from the perspective of the AUC evaluation where it is not neccessary to initiate one.
If having more than necessary number of subjects is a problem at all? My gut feeling says no.
❝ can you run a series of sims where you include "20 more subjects than necessary" in stage 2 where a stage 2 is called for?
that could indeed be done within the (in)famous package
Power2Stage
, function power.2stage.fC()
using the argument n2.min
. At least partially because n2.min
assures a minimum sample size for stage 2, if stage 2 is called for and the estimated sample size is smaller than n2.min
.But that's not the problem Helmut has described, at least as I understand it. Here we initiate a stage 2 from the perspective of the AUC evaluation where it is not neccessary to initiate one.
If having more than necessary number of subjects is a problem at all? My gut feeling says no.
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- Two PK metrics: Inflation of the Type I Error Helmut 2017-11-12 11:57
- Two PK metrics: Inflation of the Type I Error? d_labes 2017-11-12 17:46
- A place to start ElMaestro 2017-11-12 21:43
- A place to start?d_labes 2017-11-13 16:02
- A place to start? Helmut 2017-11-13 16:51
- Scientific gut feeling d_labes 2017-11-15 10:34
- Five minutes gone - power.tsd.2m() arose d_labes 2017-11-15 13:15
- Scientific gut feeling d_labes 2017-11-15 10:34
- A better place to start. ElMaestro 2017-11-14 00:04
- Nope Helmut 2017-11-14 00:21
- Nope nobody 2017-11-14 08:11
- I've meditated hard ElMaestro 2017-11-14 12:41
- Nope Helmut 2017-11-14 00:21
- A place to start? Helmut 2017-11-13 16:51
- A place to start?d_labes 2017-11-13 16:02