Bioequivalence and Bioavailability Forum 05:41 CEST

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

A place to start? [Two-Stage / GS Designs]

posted by d_labes - Berlin, Germany, 2017-11-13 16:02  - Posting: # 17974
Views: 2,157

Dear ElMaestro,

» can you run a series of sims where you include "20 more subjects than necessary" in stage 2 where a stage 2 is called for?

that could indeed be done within the (in)famous package Power2Stage, function power.2stage.fC() using the argument n2.min. At least partially because n2.min assures a minimum sample size for stage 2, if stage 2 is called for and the estimated sample size is smaller than n2.min.

But that's not the problem Helmut has described, at least as I understand it. Here we initiate a stage 2 from the perspective of the AUC evaluation where it is not neccessary to initiate one.

If having more than necessary number of subjects is a problem at all? My gut feeling says no.

Regards,

Detlew

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
18,698 posts in 3,983 threads, 1,237 registered users;
online 5 (0 registered, 5 guests [including 5 identified bots]).

When puzzled, it never hurts to read the primary documents –
a rather simple and self-evident principle that has, nonetheless,
completely disappeared from large sectors
of the American experience.    Stephen Jay Gould

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed