Vd/F calculation in bear [R for BE/BA]
» […] the one parameter I have been struggling to get right in any way was Vd/F. Therefore I really need to ask what method bear uses to calculate it. […]
» or is it simply Vd/F=D/(AUC0inf*Ke)?
Exactly. The wonderful thing with open source is that you can perform a “whitebox” validation. With commercial software you can only perform a “blackbox” validation (rubbish in, rubbish out).
bear’s source code is available at
Inspecting the script
NCA.ryou find in line 284
and in line 520
Hope that helps.
PS: The same formula is used in Phoenix/WinNonlin.
PPS: IMHO, the “volume of distribution” after an extravascular dose (if no i.v. dose was administered in the same study) bears [pun!] limited – if any – meaning. Since F is unknown, what’s the purpose of reporting V/F?
The quality of responses received is directly proportional to the quality of the question asked. ☼