Bioequivalence and Bioavailability Forum 06:39 CET

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

Vd/F calculation in bear [R for BE/BA]

posted by CECIF - Colombia, 2017-11-02 22:45  - Posting: # 17964
Views: 2,673

Hello everybody

I have been using bear for bioequivalence calculation since version 6.2. I consider it very useful and approachable and I am really grateful with yjlee168 for it.

For regulations in my country I have to make my own validation of bear's estimates. therefore I have been using a study of my own and I comapre my result with the ones I got from bear with the same study. Most of the values came out quite well, on exception of some of the AUC0inf and AUC0t mostly on the last sampling times which came out a little higher in my calculations (I can only suposse it is because of the decimal numbers).

However, the one parameter I have been struggling to get right in any way was Vd/F. Therefore I really need to ask what method bear uses to calculate it. I have been trying different equations to get it, but I failed in every one.
is it Vd/F= D*Ka/(I(Ka-Ke))? with ka from the residuals method or the wagner-nelson method?
or is it simply Vd/F=D/(AUC0inf*Ke)?
Vd/F= Apparent volume of distribution
D=dosage
I=intercept of the concentration vs time graph (x=0) when extrapolating the excretion line
ke=elimination constant (lambda z)
ka=absortion constant

Feel free to correct any missconception from my equations too.

I would really appreciate any light you could shed on this matter.

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
18,882 posts in 4,026 threads, 1,271 registered users;
online 4 (0 registered, 4 guests [including 4 identified bots]).

Some scientists claim that hydrogen, because it is so plentiful,
is the basic building block of the universe.
I dispute that. I say there is more stupidity than hydrogen,
and that is the basic building block of the universe.    Frank Zappa

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed