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Back to the forum  Query: 2017-11-18 22:26 CET (UTC+1h)

Earth-mover's distance [Nonparametrics]

posted by ElMaestro - Denmark, 2017-10-27 14:58  - Posting: # 17933
Views: 453

Hi all,

re. FDA Ciclosporine draft guidance:

Does anyone know where I should start to get to grips with Earth-mover's distance for real and in practice?
Wikipedia, the reference indicated in the guidance and some random googling hasn't given me a solid basis for understanding anything, much less for doing anything of value with it.

Note that the footnote opens up the possibility of using some other statistical similarity measures, and I hope to go that way, but let us for the purpose of this thread discuss EMD only :-D:confused::pirate:

I could be wrong, but…

Best regards,

No, I still don't believe much in the usefulness of IVIVCs for OIPs when it comes to picking candidate formulations for the next trial. This is not the same as saying I don't believe in IVIVCs.

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