Atorvastatin intra-subject Variability [Study As­sess­ment]

posted by nobody – 2017-09-27 12:11 (2393 d 13:29 ago) – Posting: # 17832
Views: 4,950

❝ Chance?

Maybe, but...

❝ Better assay?

No

❝ Design differences?

How?

❝ Lesser within-batch variability (-ies) than in the studies you compare to?

Variability has been attributed to various physiological sources, including e.g. liver function, transporter status:

https://www.ncbi.nlm.nih.gov/pubmed/22167570
https://www.ncbi.nlm.nih.gov/pubmed/21548957
https://www.ncbi.nlm.nih.gov/pubmed/20818835

Kindest regards, nobody

Complete thread:

UA Flag
Activity
 Admin contact
22,984 posts in 4,822 threads, 1,652 registered users;
59 visitors (0 registered, 59 guests [including 10 identified bots]).
Forum time: 01:41 CEST (Europe/Vienna)

You can’t fix by analysis
what you bungled by design.    Richard J. Light, Judith D. Singer, John B. Willett

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5