Bioequivalence and Bioavailability Forum • CVs for untransformed data

CVs for untransformed data [Software]

posted by Helmut – Vienna, Austria, 2017-09-02 17:57 (2426 d 20:46 ago) – Posting: # 17765
Views: 12,821

Hi mittyri,

❝ citing the WNL guide:

❝ intrasubject CV = sqrt(Var(Residual)) / RefLSM

❝ where RefLSM is the Least Squares Mean of the reference treatment.

❝

❝ For me even the formula above is strange. You are dividing overall standard deviation (calculated for both T and R) by LSMean of reference product only. Does that mean that if we inverse R to T, CV should change too?

Not necessarily should but will. I suggest dividing by the (weighted) global mean.

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Complete thread:

Lack of IntersubjectCV in PHX yicaoting 2017-09-01 11:09 [Software]
- CVs for untransformed data mittyri 2017-09-02 15:46
  - CVs for untransformed dataHelmut 2017-09-02 15:57
    - CVs for untransformed data yicaoting 2017-09-02 17:50
      - CVs for untransformed data Helmut 2017-09-02 19:20
        
        CVs for untransformed data yicaoting 2017-09-02 23:26
        
        N(μ, σ²) Helmut 2017-09-04 13:32
        
        N(μ, σ²) yicaoting 2017-09-05 02:46
  - CVs for untransformed data yicaoting 2017-09-03 08:19
    - CVs for untransformed data mittyri 2017-09-03 08:41
      - CVs for untransformed data yicaoting 2017-09-04 11:35