How To calculate CVintra and CVinter [RSABE / ABEL]
Hope all of you are doing well.
I have 2 questions regarding 2 treatment 3 period 3 sequence BE study:
1) How to calculate CVintra and CVinter for Cmax using proc GLM;
(According to my knowledge; in 2*2*2 we use proc mixed and we use Residual to get CVintra and Subject(Sequence) to get CVinter using the following formulas):
However, In proc GLM, I don't get the residual value to use in CVintra equation as I know that if CVintra > 30%, we have to use proc glm no proc Mixed. The code I am using for proc GLM is:
proc glm data=ee;
class subject treat per sequence;
model auc0_t=treat per sequence subject(sequence);
means treat /hovtest=levene(type=abs);
output out=resids r=residual;
Using this, I get the sum of the squared residuals but I dont know which to use?!!.
Merged from follow-up post [Helmut]:
Can any one tell me how can I get the CVinter and CVintra for Partial replicate (2*3*3).
I followed the code by FDA for partial replicate and I got ilat and dlat and I know the difference between both of them.
However, I don't get the subject(sequence) to use for Cvinter and I don't know which value to use for Cvinter?
2) For Outlier Analysis using Residuals, Do I have to check for the outliers of each parameter separated? As for example; In AUC0-INF I have missing data values. However, in AUC0-T and Cmax I have no missing ones.
Edit: Relax; see also this post #8. 21 hours ≠ 14 days. You can edit you original post for 24 hours; see there. Follow-up post deleted. [Helmut]
- How To calculate CVintra and CVinter - Mohamed Yehia, 2017-08-15 15:33 [RSABE / ABEL]