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Back to the forum  2018-07-20 11:27 CEST (UTC+2h)

CVintra for Cmax > AUC, therefore use AUC for sample size? [Power / Sample Size]

posted by Helmut Homepage - Vienna, Austria, 2017-08-07 18:40  - Posting: # 17674
Views: 3,181

Hi nobody,

» Found this here:
» https://www.ncbi.nlm.nih.gov/pubmed/28257283
» […] if I understand this correctly, the authors say, CVintra for Cmax is generally higher than for AUC, therefore use AUC to estimate the sample size of your study.

Ah – the formerly pink, now black journal. ;-)

» Did I get this right?

At least this is what the last sentence of the abstract says: “Hence, CV derived from AUC instead of Cmax should be used in sample-size calculation to achieve a sufficient, yet practical, test power.
”

» Any thoughts on this approach?

Outright bizarre. Since the authors are of a CRO, maybe the love failed studies in order to repeat them? Do you have a copy to share?

Cheers,
Helmut Schütz
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