CVintra for Cmax > AUC, therefore use AUC for sample size? [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2017-08-07 20:40 (2425 d 15:22 ago) – Posting: # 17674
Views: 8,744

Hi nobody,

❝ Found this here:

https://www.ncbi.nlm.nih.gov/pubmed/28257283

❝ […] if I understand this correctly, the authors say, CVintra for Cmax is generally higher than for AUC, therefore use AUC to estimate the sample size of your study.


Ah – the formerly pink, now black journal. ;-)

❝ Did I get this right?


At least this is what the last sentence of the abstract says: “Hence, CV derived from AUC instead of Cmax should be used in sample-size calculation to achieve a sufficient, yet practical, test power.
”

❝ Any thoughts on this approach?


Outright bizarre. Since the authors are of a CRO, maybe the love failed studies in order to repeat them? Do you have a copy to share?

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