Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

Back to the forum  2018-07-20 11:32 CEST (UTC+2h)

forced BE? [Design Issues]

posted by Helmut Homepage - Vienna, Austria, 2017-08-07 14:00  - Posting: # 17669
Views: 4,818

Hi ElMaestro,

» That is indeed why we need to apply more bootstrapping in BE.

Duno whether we need it. Of course, one can do it since the GL only speaks about “an appropriate sample size calculation.” Whatever that might be.

» It, too, tells what sample size we need, but in contrast to ordinary power calcs it allows one to take into account that residuals may not be normal even though the evaluation itself makes that assumption.

Right. But IMHO, the quality of bootstrapping depends on the input. Remember what you once wrote?

OT: In your current signature you claim to have “an affair with the bootstrap”. Really an affair? I mean, does it respond to your love? Or is it just calf love?

Cheers,
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. ☼
Science Quotes

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
18,547 posts in 3,941 threads, 1,192 registered users;
online 17 (1 registered, 16 guests [including 11 identified bots]).

If there is an exception to any rule,
and if it can be proved by observation,
that rule is wrong.    Richard Feynman

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed