compromised power [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2017-08-03 16:04  – Posting: # 17655
Views: 12,879

Hi Darya,

» The sample size by the formula I used:
» n=28

To keep everything equal you should convert the standard deviation to the CV. Hence,

library(PowerTOST)
sampleN.TOST(CV=se2CV(0.3))

+++++++++++ Equivalence test - TOST +++++++++++
            Sample size estimation
-----------------------------------------------
Study design:  2x2 crossover
log-transformed data (multiplicative model)

alpha = 0.05, target power = 0.8
BE margins = 0.8 ... 1.25
True ratio = 0.95,  CV = 0.3068783

Sample size (total)
 n     power
42   0.818541


Of course higher than the 28 by the dubious formula. As David mentioned above (quoting Zhang’s paper) power is compromised. Let’s check how much:

power.TOST(CV=se2CV(0.3), n=28)
[1] 0.6250166

Oops!

Cheers,
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. ☼
Science Quotes

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,487 posts in 4,135 threads, 1,336 registered users;
online 14 (0 registered, 14 guests [including 8 identified bots]).
Forum time (Europe/Vienna): 18:58 CEST

If debugging is the process of removing bugs,
then programming must be the process of putting them in.    Edsger W. Dijkstra

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5