Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

Back to the forum  2018-06-19 01:36 CEST (UTC+2h)

sample size in bioequivalence studies [Power / Sample Size]

posted by daryazyatina - Ukraine, 2017-08-03 09:34  - Posting: # 17646
Views: 5,837

Hi, guys!

Today I have a new question related to the the sample size formula for average bioequivalence.

Before now I сalculated the sample size for ABE by formula:
[image]
(described in the book Shein-Chung Chow, Jun Shao and Hansheng Wang "Sample size calculations in clinical research" Copyright © 2003 by Marcel Dekker (Chapter 10. Bioequivalence Testing) http://www.crcnetbase.com/doi/book/10.1201/9780203911341)

I decided to try to calculate the sample size in R with package "PowerTOST" and function sampleN.TOST()

Comparing the results of the calculation in R and calculation with formula Shein-Chung Chow, Jun Shao and Hansheng Wang, I realized that they are different. I looked at the articles and books that this function refers to, and understand that different formulas are used.

On this basis, I had a question. What formula should I use to calculate the sample size for the ABE using two one-sided tests?

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
18,385 posts in 3,905 threads, 1,172 registered users;
online 14 (1 registered, 13 guests [including 10 identified bots]).

You can’t fix by analysis
what you bungled by design.    Richard J. Light, Judith D. Singer, John B. Willett

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed