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sample size in bioequivalence studies [Power / Sample Size]

posted by daryazyatina - Ukraine, 2017-08-03 09:34  - Posting: # 17646
Views: 7,097

Hi, guys!

Today I have a new question related to the the sample size formula for average bioequivalence.

Before now I сalculated the sample size for ABE by formula:
(described in the book Shein-Chung Chow, Jun Shao and Hansheng Wang "Sample size calculations in clinical research" Copyright © 2003 by Marcel Dekker (Chapter 10. Bioequivalence Testing)

I decided to try to calculate the sample size in R with package "PowerTOST" and function sampleN.TOST()

Comparing the results of the calculation in R and calculation with formula Shein-Chung Chow, Jun Shao and Hansheng Wang, I realized that they are different. I looked at the articles and books that this function refers to, and understand that different formulas are used.

On this basis, I had a question. What formula should I use to calculate the sample size for the ABE using two one-sided tests?

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