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Back to the forum  Query: 2017-08-24 06:54 CEST (UTC+2h)
 

package ncappc in R [R for BE/BA]

posted by daryazyatina - Ukraine, 2017-07-25 15:12  - Posting: # 17608
Views: 402

(edited by daryazyatina on 2017-07-25 15:32)

Good day, guys!

I have some data about concentration and time of this concentration from the literature data. I want to compare the data from WinNonLin with data from RStudio.
This .csv file I imported in RStudio.
ID,TIME,DV
1,0,0
1,0.33,358
1,0.66,585
1,1,645
1,1.33,792
1,1.66,761
1,2,882
1,2.5,926
1,3,1114
1,3.5,1111
1,4,1070
1,5,752
1,6,557
1,8,351
1,10,222
1,12,137
1,16,83
1,24,52

and this code I used to calculate the pharmacokinetic parameters:
ncappc(obsFile=system.file("extdata","concentrationb2.csv", package = "ncappc"),
       concUnit = "ng/mL",
       timeUnit = "h",
       doseUnit = "g",
       adminType = "extravascular",
       doseType = "ns",
       method = "linear",
       printOut = FALSE,
       psnOut=FALSE,
       noPlot=TRUE,
       LambdaExclude = c(0,0.33,0.66,1,1.33,1.66,2,2.5,3,3.5,4)
      )


I need calculate elimination constant with time points from 5h to 24h.
After all RStudio calculate pharmacokinetic parameters BUT the elimination constant is incorrectly calculated.
What I do wrong?


Edit: Category changed; see also this post #1. [Helmut]

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