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Back to the forum  Query: 2017-09-24 14:16 CEST (UTC+2h)
 

Metabolite back conversion [Bioanalytics]

posted by samar sameh - Jordan, 2017-07-16 07:47  - Posting: # 17554
Views: 597

Hello Every body:
can any one please share with me the procedure conducted for the back conversion test during bioanalytical method validation. what we do is to spike the LLOQ samples of the drug with the maximum expected concentration of the metabolite, and the calculating the accuracy of the LLOQ through a calibration curve of the drug the covers a range from LLOQ to ULOQ. every time we have a failed accuracy, i dont know if there is really a back conversion or if our procedure is misleading.

BR
S.S

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