Bioequivalence and Bioavailability Forum

Dear d_labes
Thank you for solving the puzzle.

I checked it in comparing to the CSH parameterization in which we had Var(1) and Var(2) as sig_BR2=G(1,1)=Var(1)
sig_BT2=G(2,2)=Var(2).

I referred Design and Anaysis of BA and BE Studies Second Edition by CHOW & LIU (Page 405) for Subject by formulation interaction which confirmed CSH model for
sig_D2=Var(1)+Var(2)-2*CSH*sqrt(Var(1))*sqrt(Var(2)).

We are not going for individual bioequivalence is was only for the sake of my understanding.
I would like to study in detail about Average, Population and Individual bioequivalence. Kindly send some reference for the same.

Regards,
Atish