Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log-in |  Register |  Search

Back to the forum  Query: 2017-09-25 06:26 CEST (UTC+2h)
 

Estimation within-subject CV [Power / Sample Size]

posted by Mikkabel - Belgium, 2017-07-07 10:13  - Posting: # 17515
Views: 966

Dear all,

I need your expertise regarding the estimation of the CVintra. Indeed, I am aware that the within subject CV should be calculed based on the sw² obtained following a full (or partially) replicate design study but my question is:

- is it relevant to estimate the within subject CV based on the MSE obtained following a classical CO study (analysed with the EMA requiments e.g period, formulation and subject within sequence as fixed effect)? I precise that it is just an estimation to have an idea if it is relevant to performed a replicate design study or not.

I heard in a symposium that the CV obtained from the MSE should be a good estimator of the real within subject CV, could you confirm ? (or not ;-))

Thank you,
Kind regards,


Edit: Category changed; see also this post #1. [Helmut]

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum | Admin contact
17,323 Posts in 3,705 Threads, 1,067 registered users;
30 users online (0 registered, 30 guests).

The belief that there is only one truth and
that oneself is in possession of it,
seems to me the deepest root of all
that is evil in the world.    Max Born

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
XHTML/CSS RSS Feed