Estimation within-subject CV [Power / Sample Size]
Dear all,
I need your expertise regarding the estimation of the CVintra. Indeed, I am aware that the within subject CV should be calculed based on the sw² obtained following a full (or partially) replicate design study but my question is:
- is it relevant to estimate the within subject CV based on the MSE obtained following a classical CO study (analysed with the EMA requiments e.g period, formulation and subject within sequence as fixed effect)? I precise that it is just an estimation to have an idea if it is relevant to performed a replicate design study or not.
I heard in a symposium that the CV obtained from the MSE should be a good estimator of the real within subject CV, could you confirm ? (or not )
Thank you,
Kind regards,
Edit: Category changed; see also this post #1. [Helmut]
I need your expertise regarding the estimation of the CVintra. Indeed, I am aware that the within subject CV should be calculed based on the sw² obtained following a full (or partially) replicate design study but my question is:
- is it relevant to estimate the within subject CV based on the MSE obtained following a classical CO study (analysed with the EMA requiments e.g period, formulation and subject within sequence as fixed effect)? I precise that it is just an estimation to have an idea if it is relevant to performed a replicate design study or not.
I heard in a symposium that the CV obtained from the MSE should be a good estimator of the real within subject CV, could you confirm ? (or not )
Thank you,
Kind regards,
Edit: Category changed; see also this post #1. [Helmut]
Complete thread:
- Estimation within-subject CVMikkabel 2017-07-07 10:13
- Estimation within-subject CV ElMaestro 2017-07-07 10:17
- CVwR ~ CVwT ~ CVw? Helmut 2017-07-07 16:09
- CVwR ~ CVwT ~ CVw? zizou 2017-07-08 15:29
- CVwR = CVwT < CVw‽ Helmut 2017-07-08 16:45
- 'whatif' plotting from 4X2 to 2X2 mittyri 2017-07-08 23:47
- CVwR ~ CVwT ~ CVw? ElMaestro 2017-07-09 00:16
- CVwR ~ CVwT ~ CVw? zizou 2017-07-09 02:13
- CVwR = CVwT < CVw‽ Helmut 2017-07-08 16:45
- CVwR ~ CVwT ~ CVw? zizou 2017-07-08 15:29