Bioequivalence and Bioavailability Forum • increased solubility = different PK profile?

increased solubility = different PK profile? [Dissolution / BCS / IVIVC]

posted by nobody – 2017-06-08 20:57 (2511 d 07:00 ago) – Posting: # 17471
Views: 14,027

Hmmm, but with lower than REF systemic exposure you should not be able to proof efficacy, I guess?

—
Kindest regards, nobody

Complete thread:

increased solubility = different PK profile? Dr_Dan 2017-06-08 16:57 [Dissolution / BCS / IVIVC]
- increased solubility = different PK profile? nobody 2017-06-08 17:16
- increased solubility = different PK profile? Helmut 2017-06-08 17:18
  - increased solubility = different PK profile? nobody 2017-06-08 17:22
    - ka vs. Cmax Helmut 2017-06-09 14:35
      - ka vs. Cmax nobody 2017-06-09 16:27
      - ka vs. Cmax mittyri 2017-06-10 14:59
- increased solubility = different PK profile? ElMaestro 2017-06-08 17:24
  - increased solubility = different PK profile? Dr_Dan 2017-06-08 17:36
    - increased solubility = different PK profile? nobody 2017-06-08 17:43
    - increased solubility = different PK profile? Ohlbe 2017-06-08 18:23
      - increased solubility = different PK profile? nobody 2017-06-08 18:58
    - increased solubility = different PK profile? ElMaestro 2017-06-08 18:45
      - increased solubility = different PK profile?nobody 2017-06-08 18:57
        
        increased solubility = different PK profile? nobody 2017-06-09 09:38
- increased solubility = different PK profile? Kiran 2017-06-24 11:02

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