Bioequivalence and Bioavailability Forum • More samples

More samples – less variability (for Cmax) [Design Issues]

posted by nobody – 2017-05-23 16:31 (2526 d 20:00 ago) – Posting: # 17397
Views: 4,457

❝ Would be fun to simulate that. Makes a nice paper.

...same thought here, thought about reviving my old "S-plus" files with "retro-NONMEM" sim approach to study influence of analytical variability on parameters estimates in BE-trials :-)

But no time for the next months.

Have a special compound here, as some percentage of volunteers simply end up with low exposure, apparently nobody (no, not me...) knows why. Would be the classical situation were more samples is only more $$$, no better data, or? ;-)

—
Kindest regards, nobody

Complete thread:

More samples – less variability (for Cmax)? nobody 2017-05-23 09:07 [Design Issues]
- More samples – less variability (for Cmax) Helmut 2017-05-23 12:56
  - Sample volume Ohlbe 2017-05-23 14:14
    - Sample volume nobody 2017-05-23 14:50
      - Sample volume Ohlbe 2017-05-23 19:00
  - More samples – less variability (for Cmax)nobody 2017-05-23 14:31