lin-up/log-down is bear’s default [🇷 for BE/BA]
Dear Pjs,
bear = free software (open source) ≠ freeware.
Note that the lin-up/log-down trapezoidal method is the default in bear – and for good reasons (IMHO, the linear rule should abandoned since it overestimates the AUC in the distribution/elimination phase). I got:
Lin-up/log-down trapezoidal method:
If concentrations are increasing or equal in the interval [1, 2] use the linear trapezoidal, i.e.,
1435.682 ≠ 1434.606. Close, but… Is it possible that in your original data set times and/or concentrations are given with more significant digits than you posted here? Please check.
If you have to use the linear trapezoidal method (stupid SAP, SOP, boss), see this post and change the
❝ […] this wonderful freeware
bear = free software (open source) ≠ freeware.
❝ […] if i do manual calculation of AUC by trapezoid rule by formula, AUC is coming to 1478.681 instead of 1435.682 by bear.
Note that the lin-up/log-down trapezoidal method is the default in bear – and for good reasons (IMHO, the linear rule should abandoned since it overestimates the AUC in the distribution/elimination phase). I got:
time conc bear incr/equal linear lin/log
0.00 0.000 0.000 yes 0.000 0.000
1.00 0.000 0.000 yes 0.000 0.000
1.50 0.000 0.000 yes 0.000 0.000
2.00 0.000 0.000 yes 0.000 0.000
2.50 0.000 0.000 yes 0.000 0.000
3.00 0.000 0.000 yes 0.000 0.000
3.50 0.000 0.000 yes 0.000 0.000
4.00 1.518 0.380 yes 0.380 0.380
4.33 5.027 1.459 yes 1.459 1.459
4.67 12.700 4.473 yes 4.473 4.473
5.00 22.210 10.233 no 10.233 10.088
5.33 18.013 16.846 yes 16.870 16.725
5.67 22.332 23.704 yes 23.729 23.583
6.00 30.500 32.422 no 32.446 32.231
6.33 24.290 41.423 yes 41.486 41.271
6.67 31.676 50.937 yes 51.000 50.785
7.00 32.647 61.551 yes 61.614 61.398
7.50 45.512 81.091 yes 81.154 80.938
8.00 95.827 116.425 yes 116.488 116.273
10.00 120.261 332.513 no 332.576 331.437
12.00 89.598 540.870 no 542.435 539.794
16.00 41.572 791.036 no 804.775 789.960
24.00 24.576 1049.699 no 1069.367 1048.623
36.00 9.237 1237.802 no 1272.245 1236.725
48.00 4.897 1319.870 no 1357.049 1318.793
72.00 1.976 1397.115 no 1439.525 1396.039
96.00 1.287 1435.682 no 1478.681 1434.606
Lin-up/log-down trapezoidal method:
If concentrations are increasing or equal in the interval [1, 2] use the linear trapezoidal, i.e.,
AUC1–2 = 0.5(t2–t1)(C2+C1)
If concentrations are decreasing in the interval [1, 2] use the log trapezoidal, i.e.,AUC1–2 = (t2–t1)(C2–C1)∕log(C2∕C1)
1435.682 ≠ 1434.606. Close, but… Is it possible that in your original data set times and/or concentrations are given with more significant digits than you posted here? Please check.
If you have to use the linear trapezoidal method (stupid SAP, SOP, boss), see this post and change the
Setting
for trapezoidal AUC
from 0
to 1
.—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- AUC calculation in bear pjs 2017-05-21 15:57
- lin-up/log-down is bear’s defaultHelmut 2017-05-21 17:32
- lin-up/log-down any regulatory recommendation? pjs 2017-05-21 19:08
- lin-up/log-down any regulatory recommendation? Helmut 2017-05-21 19:14
- lin-up/log-down any regulatory recommendation? pjs 2017-05-21 19:33
- lin-up/log-down any regulatory recommendation? Helmut 2017-05-21 19:14
- lin-up/log-down is bear’s default yjlee168 2017-05-21 20:08
- lin-up/log-down is bear’s default Yura 2017-05-25 12:52
- zero (0), missing (NA), or BLLOQ (0 or NA) in bear (II) yjlee168 2017-05-25 14:38
- zero (0), missing (NA), or BLLOQ (0 or NA) in bear (II) Yura 2017-05-25 15:17
- zero (0), missing (NA), or BLLOQ (0 or NA) in bear (II) yjlee168 2017-05-25 14:38
- lin-up/log-down is bear’s default Yura 2017-05-25 12:52
- lin-up/log-down is bear’s default Astea 2017-05-22 02:12
- Never use Excel Helmut 2017-05-22 13:19
- lin-up/log-down any regulatory recommendation? pjs 2017-05-21 19:08
- lin-up/log-down is bear’s defaultHelmut 2017-05-21 17:32