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RegisterIntersubject variation in replicated BE study [General Statistics]
Dear d_labes/all,
subject-by-formulation interaction variance is
sig_D^2=FA(1,1)^2+FA(2,1)^2-2*FA(1,1)*FA(2,1)
As far as WinNonlin is concerned Under 'Final Variance Parameters' values of lambda(1,1)_11, lambda(1,2)_11 and lambda(2,2)_11 corresponds to SAS output of FA(1,1), FA(2,1) and FA(2,2) respectively.
Based on above mentioned parameters we can calculate inter and intra subject variation.
Regards,
Atish
subject-by-formulation interaction variance is
sig_D^2=FA(1,1)^2+FA(2,1)^2-2*FA(1,1)*FA(2,1)
As far as WinNonlin is concerned Under 'Final Variance Parameters' values of lambda(1,1)_11, lambda(1,2)_11 and lambda(2,2)_11 corresponds to SAS output of FA(1,1), FA(2,1) and FA(2,2) respectively.
Based on above mentioned parameters we can calculate inter and intra subject variation.
Regards,
Atish
Complete thread:
- Intersubject variation in replicated BE study atish_azad 2008-03-20 11:33 [General Statistics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Intersubject variation in replicated BE study d_labes 2008-03-26 13:34
- Intersubject variation in replicated BE study atish_azad 2008-03-31 15:02
- Intersubject variation in replicated BE study Jaime_R 2008-03-31 15:09
- Intersubject variation in replicated BE studyatish_azad 2008-04-01 06:15
- Intersubject variation in replicated BE study d_labes 2008-04-01 10:01
- Intersubject variation in replicated BE study atish_azad 2008-04-02 15:27
- Intersubject variation in replicated BE study Jaime_R 2008-03-31 15:09
- Intersubject variation in replicated BE study atish_azad 2008-03-31 15:02
- Intersubject variation in replicated BE study d_labes 2008-03-26 13:34
Ing. Helmut Schütz