Bioequivalence and Bioavailability Forum • TRR / RTT Design

TRR / RTT Design [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2017-05-09 18:56 (2537 d 08:37 ago) – Posting: # 17336
Views: 8,495

Hi Yura,

❝ GMR - the average difference T1-T2

❝ CI - Student's t-test for dependent samples (for 17)

I guess by T1 you mean T in period 2 and by T2 T in period 3.
As said above such an evaluation assumes no period effects. Only if the period effect would be exactly zero, the difference in period means would be an unbiased estimate of the treatment effect. Your comparison is not correct. I assume when you run the same test on RR you will also get ‘strange’ results.

❝ Results for T-T does not take into account?

Does not take what into account?

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Complete thread:

TRT / RTR Design Yura 2017-05-01 09:34
- TRT / RTR Design mittyri 2017-05-02 18:38
  - TRT / RTR Design Yura 2017-05-02 21:19
    - TRT / RTR Design Helmut 2017-05-02 22:04
      - TRT / RTR Design Yura 2017-05-03 07:41
        
        TRT / RTR Design Helmut 2017-05-03 21:49
        
        TRT / RTR Design ElMaestro 2017-05-03 22:04
        
        TRT / RTR Design Helmut 2017-05-06 18:33
        
        TRR / RTT Design Yura 2017-05-09 11:35
        
        TRR / RTT Design Helmut 2017-05-09 13:06
        
        TRR / RTT Design Yura 2017-05-09 16:18
        
        TRR / RTT DesignHelmut 2017-05-09 16:56
        
        TRR / RTT Design Yura 2017-05-09 17:36
        
        TRR / RTT Design Helmut 2017-05-09 17:53
        
        TRR / RTT Design Yura 2017-05-09 18:07