Bioequivalence and Bioavailability Forum • endogenous compounds

endogenous compounds [Regulatives / Guidelines]

posted by martin – Austria, 2017-05-08 23:19 (2543 d 15:19 ago) – Posting: # 17325
Views: 3,249

Hi Helmut,

Thank you very much for your response - much appreciated.

Regarding distributions - thank you for the reminder & sorry for not being clear

We look at the end of the profile assuming C0=C1 this would lead to


C0     <- rlnorm(n=1e6, meanlog=log(1)-0.5*log(0.3^2+1), sdlog=sqrt(log(0.3^2+1)))

C1     <- rlnorm(n=1e6, meanlog=log(1)-0.5*log(0.3^2+1), sdlog=sqrt(log(0.3^2+1)))

C1.adj <- C1/C0

hist(log(C1.adj)) # taking the log-normal distribution into account

best regards

Martin

Complete thread:

endogenous compounds martin 2017-05-08 19:50 [Regulatives / Guidelines]
- endogenous compounds Helmut 2017-05-08 21:10
  - endogenous compoundsmartin 2017-05-08 21:19