Interval between groups [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2017-05-08 21:02 (2515 d 17:03 ago) – Posting: # 17321
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Hi mittyri and all,

the p-value of the Group-by-Treatment interaction seemingly does not depend on the interval between groups. In 51% of the studies the interval was three days or less but in some substantially longer (i.e., steady state studies where the clinic was occupied). The bubbles’ area, the linear regression, and the loess curve are scaled/weighed by the sample size.

[image]

slope: 0.011196 (p 0.165)

[image]

slope: 0.010589 (p 0.186)


Therefore, we should not worry. The FDA defines “greatly separated in time” as “months apart, for example”.

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