Bioequivalence and Bioavailability Forum • Inclusion of 3 consecutive non-zero conc data with Cmax as a last Con in PK

Inclusion of 3 consecutive non-zero conc data with Cmax as a last Con in PK [PK / PD]

posted by VSP – India, 2017-05-07 23:53 (2537 d 19:30 ago) – Posting: # 17315
Views: 2,116

Hi All,

I would like to request you please explain the rationale behind the following statement:
Concentration Time profile of a drug must have at least 3 consecutive non-zero concentration data and of which the Cmax must not be the last quantifiable concentration in order to be included in the pharmacokinetic and statistical analyses.

Thanks in advance

VSP

Complete thread:

Inclusion of 3 consecutive non-zero conc data with Cmax as a last Con in PKVSP 2017-05-07 21:53