Inclusion of 3 consecutive non-zero conc data with Cmax as a last Con in PK [PK / PD]

posted by VSP – India, 2017-05-07 21:53 (1190 d 09:35 ago) – Posting: # 17315
Views: 1,416

Hi All,

I would like to request you please explain the rationale behind the following statement:
Concentration Time profile of a drug must have at least 3 consecutive non-zero concentration data and of which the Cmax must not be the last quantifiable concentration in order to be included in the pharmacokinetic and statistical analyses.

Thanks in advance

VSP

Complete thread:

Activity
 Admin contact
20,989 posts in 4,375 threads, 1,460 registered users;
online 7 (0 registered, 7 guests [including 4 identified bots]).
Forum time: Monday 07:28 CEST (Europe/Vienna)

[Those] who have an excessive faith in their theories or in their
ideas are not only poorly disposed to make discoveries, but they
also make very poor observations.    Claude Bernard

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5