## TRT / RTR Design [RSABE / ABEL]

Dear Yura,

you should use all data included in PK analysis (ie all subjects) for CI estimation.
To extent the limits you need to calculate variability of RR, that is, 50% of subjects.
A hint: even if you try to calculate variability of RR for overall dataset, the majority of software (at least SAS PHX, R) is smart enough not to include the subjects with one R.

» The appropriate sample size must be.
» Alpha correction.
what did you mean here?

Kind regards,
Mittyri