Bioequivalence and Bioavailability Forum • TIE depends on CVwR (and n)

TIE depends on CVwR (and n) [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2017-04-26 20:00 (2548 d 10:40 ago) – Posting: # 17270
Views: 11,025

Hi Yura,

❝ Adjusted alpha is used to construct confidence intervals of the pharmacokinetic parameters for the index T-P?

What do you mean by “the index T-P”? For the EMA use the ‘Method A’ or ‘Method B’ as given in the Q&A-document. But instead of using the nominal α of 0.05 (i.e., the 100(1–2α) = 90% CI) apply the respective adjusted α. If the TIE would be inflated with α 0.05, the adjusted CI is always wider (i.e., conservative).

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Complete thread:

question of adjustment Yura 2017-04-25 15:14
- TIE depends on CVwR (and n) Helmut 2017-04-26 14:17
  - TIE depends on CVwR (and n) Yura 2017-04-26 17:28
    - TIE depends on CVwR (and n)Helmut 2017-04-26 18:00
      - TIE depends on CVwR (and n) Yura 2017-04-26 18:55
        
        TIE depends on CVwR (and n) Yura 2017-04-28 11:13
        
        TIE = p(BE) at expanded limits Helmut 2017-04-28 19:16
        
        TIE = p(BE) at expanded limits Yura 2017-04-29 13:01
  - TIE depends on CVwR (and n) pjs 2018-02-28 14:33
    - TIE depends on CVwR (and n) Helmut 2018-02-28 14:48
      - TIE depends on CVwR (and n) pjs 2018-03-01 07:35
        
        Comparing methods for (S)ABE Helmut 2018-03-01 13:32
        
        Comparing methods for (S)ABE pjs 2018-03-05 14:50
        
        Simulating the Null Helmut 2018-03-05 17:40
    - Adjusting α Helmut 2018-03-07 16:21