absorption / elimination [PK / PD]
» Can we define the absorption phase and elimination phase with concentration time data/Plot?
There is no “absorption/elimination phase”. Both absorption / elimination start almost immediately with dosing. See here (ka > kel) and there (ka = kel; flip-flop PK).
As long as drug is released from the formulation and dissolved, absorption continues until
- the formulation leaves the GIT (hence it does not make sense to sample more than 72 hours for an IR formulation) or
- the formulation proceeded in the GIT beyond the absorption window of the drug.
i % abs.
iis the multiplier of tmax. Once you have an estimate of elimination you can obtain absorption f.i. by the method of residuals or by Wagner-Nelson’s.
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- absorption phase and elimination phase VSP 2017-04-25 18:28
- absorption / eliminationHelmut 2017-04-26 13:26