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How to calculate this assumption...if AUCt is at least 80% of AUC∞... [Design Issues]

posted by javier - Spain, 2017-03-30 20:44  - Posting: # 17216
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» The purpose of your pilot is dual: To get an idea of variability so that your can dimension your pivotal trial appropriately, and to establish the time by which AUCt>0.8*AUCinf in the majority of (expected future) trial patients/volunteers.

Thanks again for the answer (y por el tiempo que me has dedicado en contestar a la pregunta, que no es poca cosa) :-)

Best regards

Javier


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

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