## How to calculate this assumption...if AUCt is at least 80% of AUC∞... [Design Issues]

» The purpose of your pilot is dual: To get an idea of variability so that your can dimension your pivotal trial appropriately, and to establish the time by which AUCt>0.8*AUCinf in the majority of (expected future) trial patients/volunteers.

Thanks again for the answer (y por el tiempo que me has dedicado en contestar a la pregunta, que no es poca cosa)

Best regards

Javier

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

Thanks again for the answer (y por el tiempo que me has dedicado en contestar a la pregunta, que no es poca cosa)

Best regards

Javier

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

### Complete thread:

- How to calculate this assumption...if AUCt is at least 80% of AUC∞... - javier, 2017-03-28 23:21 [Design Issues]
- How to calculate this assumption...if AUCt is at least 80% of AUC∞... - javier, 2017-03-30 13:36
- How to calculate this assumption...if AUCt is at least 80% of AUC∞... - ElMaestro, 2017-03-30 13:54
- How to calculate this assumption...if AUCt is at least 80% of AUC∞... - javier, 2017-03-30 14:12
- How to calculate this assumption...if AUCt is at least 80% of AUC∞... - ElMaestro, 2017-03-30 15:08
- How to calculate this assumption...if AUCt is at least 80% of AUC∞... - javier, 2017-03-30 22:44

- How to calculate this assumption...if AUCt is at least 80% of AUC∞... - ElMaestro, 2017-03-30 15:08

- How to calculate this assumption...if AUCt is at least 80% of AUC∞... - javier, 2017-03-30 14:12