intra-subject variability in a fixed sequence 2 period design [General Sta­tis­tics]

posted by DavidManteigas – Portugal, 2017-03-29 12:59 (2556 d 03:53 ago) – Posting: # 17199
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Hi Martin,

A mixed model is only useful if you have more than 2 periods (or repeated measures). In the case you are explaining, if data is missing for one period it can't be used in any way regardless of the statistical method used.

Also, I can't understand why would you use a single sequence design in bioequivalence, and also why you use a mixed effects model in a "pre-post" design... Anyway, I guess that as long as you use a random slope and intercept model, residual variability will be your "within subject variability"... but not sure how that applies to a mixed effects model with two periods only.

Regards,
David

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