1–2α CI and TOST at α 0.05 [General Sta­tis­tics]

posted by GM – India, 2017-03-28 08:50 (2558 d 07:07 ago) – Posting: # 17190
Views: 8,715

❝ ❝ If the 90%CI is one side of hundred, i.e. either (85.00-98.00) or (102.00-119.00) then there should be significant treatment effect. Is this statement correct...?


❝ Absolutely.


Hi Helmut,

Thank you for the reply.

I was also found that most of the cases above statement is correct only. But I have a situation where treatment effect is not significant even the calculated 90%CI falls one side of hundred. Is it possible..?

Actually I was used Proc GLM in SAS for this 2×2 crossover study with the model statement mentioned below:

model logCmax = Sequence Period Form Cohort Form*Cohort Subject(Sequence*Cohort)/ SS3;

Cohort was mentioned as a fixed effect because the study conducts in two groups.

The fixed effects mentioned in above the model will effect the treatment effect...? Please explain.

Regards,
GM.

Best Regards,
GM

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