Bioequivalence and Bioavailability Forum

1–2α CI and TOST at α 0.05 [General Statistics]

posted by GM – India, 2017-03-28 08:50 (2578 d 16:26 ago) – Posting: # 17190
Views: 8,814

❝ ❝ If the 90%CI is one side of hundred, i.e. either (85.00-98.00) or (102.00-119.00) then there should be significant treatment effect. Is this statement correct...?

❝

❝ Absolutely.

Hi Helmut,

Thank you for the reply.

I was also found that most of the cases above statement is correct only. But I have a situation where treatment effect is not significant even the calculated 90%CI falls one side of hundred. Is it possible..?

Actually I was used Proc GLM in SAS for this 2×2 crossover study with the model statement mentioned below:

model logCmax = Sequence Period Form Cohort Form*Cohort Subject(Sequence*Cohort)/ SS3;

Cohort was mentioned as a fixed effect because the study conducts in two groups.

The fixed effects mentioned in above the model will effect the treatment effect...? Please explain.

Regards,
GM.

—
Best Regards,
GM

Complete thread:

Relationship between calculated 90% CI and sign. treatment effect in BE GM 2017-03-27 19:40 [General Statistics]
- 1–2α CI and TOST at α 0.05 Helmut 2017-03-27 23:47
  - 1–2α CI and TOST at α 0.05GM 2017-03-28 06:50
    - 1–2α CI and TOST at α 0.05 DavidManteigas 2017-03-28 11:48
      - 1–2α CI and TOST at α 0.05 ElMaestro 2017-03-28 13:12
        
        alpha TOST is not alpha 2-sided d_labes 2017-03-28 15:12
        
        Interesting! ElMaestro 2017-03-28 21:10
        
        Google has the answer d_labes 2017-03-29 08:20
        Interesting! DavidManteigas 2017-03-29 11:16
        
        Interesting! ElMaestro 2017-03-29 11:20
        
        Interesting! DavidManteigas 2017-03-29 12:28
        
        95% CI for a test on difference d_labes 2017-03-29 14:24
        Interesting! GM 2017-03-29 20:06
        
        Interesting! nobody 2017-03-30 08:24
      - Relationship between calculated 90% CI and sign. treatment effect in BE GM 2017-03-29 12:11
        
        Relationship between calculated 90% CI and sign. treatment effect in BE DavidManteigas 2017-03-29 12:30

1–2α CI and TOST at α 0.05 [General Sta­tis­tics]

Complete thread:

1–2α CI and TOST at α 0.05 [General Statistics]