Bioequivalence and Bioavailability Forum

Dear All.

Thanks a lot for the interesting points of view!

With regard to Ohlbe's example with the 998.5 µl. I think that this is a specific mind-set as I clearly remember two groups of students during my time at university (although it does get faded).

Those that got back from the scale within minutes having written down any roughly fitting number for their analysis AND
those spending literally hours at the "4 decimal places" scale, because the Ph.Eur. says for the assay of the API "Weight 0.500 g" .
And I am sure, we all remember an example of this kind of people.

For me it seems that there is a lot of consensus here. And any apparent difference might simply be due to the fact that "should be different" for some sounds like
"have to be different" (which is not the case) and for some like
"are expected to be different in most cases, as identical real values would be a coincidence".

I think, the outcome, getting also back to Ladi's question, at the moment is simply: they are independent and can be identical, but by no means have to.
Naturally, I may have misread all prior post - again..., so any correction is welcome.

Thanks, best regards and, as making this post longer than really necessary took me to 5.30 P.M:

Have a nice evening/Schönen Feierabend!

Steven.