Calibration and QC point with same concentration [Bioanalytics]

posted by Ohlbe – France, 2017-02-23 17:20 (2590 d 16:54 ago) – Posting: # 17102
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Dear Relaxation,

❝ And why would it be common sense, that they should be different, as long as I do not use the same stock solution?


The LQC sample has to have a concentration of maximum 3 times the LLOQ, and it is in the lab's interest to have it close to 3 times (lower variability than e.g. 2 times, less chances to fail). You don't necessarily have a calibration sample at the same level of concentration.

Same for the HQC. You don't necessarily have a calibration sample in the desired zone.

It is actually only for the MQC that you could easily have the same concentration. But then, may I turn the question back: why would you want it to be at the same level of concentration as a calibration sample ?

Regards
Ohlbe

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