Bioequivalence and Bioavailability Forum • 3D

3D [Power / Sample Size]

posted by Helmut – Vienna, Austria, 2017-02-06 14:47 (3073 d 05:09 ago) – Posting: # 17021
Views: 30,032

Hi zizou,

❝ I know, someone can do it better (eg. in 3D like this kind of figure).

Your wish is my command. 3D-plots for GMR 0.95. Not sure whether they are more informative than yours.

Conventional BE (rest of the world)

[image]

Denmark: 100% included in 90% CI

[image]

I know only a few sample sizes by heart. One is for GMR 0.95, CV 30%, and target power 80%: 40 (expected power 81.6%). For Denmark with n=40 we get a mere 76.5%. Note the red contour lines at 70% power. As you discovered as well we never reach 80%. Fascinating the behavior at low CVs. If we increase the sample size, power decreases because a significant difference gets more likely. What a mess.

—
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Helmut Schütz

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Complete thread:

Denmark Curiosa (1 in 90% CI in 0.8-1.25) zizou 2017-02-05 02:03 [Power / Sample Size]
- Kudos! Helmut 2017-02-05 19:16
  - Kudos! ElMaestro 2017-02-05 21:15
    - Joking! Helmut 2017-02-06 13:27
      - Thanks, and DKMA ElMaestro 2017-02-06 13:46
        
        Power with a Danish twist Helmut 2017-02-07 15:23
        
        Danish ultra-conservatism d_labes 2017-02-08 10:57
        
        Danish ultra-conservatism Helmut 2017-02-08 11:47
    - Kudos to ElMaestro! d_labes 2017-02-06 15:06
      - Plausible Helmut 2017-02-06 17:16
        
        Plausible to me too d_labes 2017-02-06 20:25
        
        Plausible to me too ElMaestro 2017-02-06 22:30
        Plausible to me too zizou 2017-02-06 22:42
        
        THX d_labes 2017-02-07 10:01
- 3DHelmut 2017-02-06 13:47
- Denmark Curiosa (1 in 90% CI in 0.8-1.25) d_labes 2017-02-06 14:54
  - Denmark Curiosa (1 in 90% CI in 0.8-1.25) zizou 2017-02-08 21:03
    - Alternative CI for BE decision d_labes 2017-02-09 11:18
      - Alternative CI for BE decision ElMaestro 2017-02-09 11:36
        
        Alternative CI for BE decision d_labes 2017-02-09 11:48
        
        How decidedly odd ElMaestro 2017-02-09 13:28
        
        How decidedly odd zizou 2017-02-09 14:42
        
        Alternative CI for BE decision Helmut 2017-02-09 13:41
        
        No alternative d_labes 2017-02-09 20:37
        
        No alternative ElMaestro 2017-02-10 13:51
        
        No alternative? mittyri 2017-02-10 15:28
        
        Dinamarka? d_labes 2017-02-10 20:10
        
        OT: Czech beer d_labes 2017-02-10 19:57
- Denmark Curiosa (1 in 90% CI in 0.8-1.25): Gone Helmut 2019-11-08 12:47