Bioequivalence and Bioavailability Forum • Kudos!

Kudos! [Power / Sample Size]

posted by ElMaestro – Denmark, 2017-02-05 22:15 (3076 d 03:08 ago) – Posting: # 17016
Views: 29,577

Hi Hötzi,

❝ Quick & extremely dirty:

❝ library(PowerTOST)

❝ 100*power.TOST(alpha=0.5, CV=0.3, theta0=0.95, n=40, theta1=0.8, theta2=1)-1.25

❝ # [1] 76.57964

I can't follow this, alpha 0.5? Substraction of 1.25% somehow from ... what?

Instead, I propose something along the lines of:

pwrDK222BE=function(alpha, CV, theta0, theta1, theta2, n)

{

  ##power the standard way is P(GMR is below theta2)-P(GMR is below theta1)

  ##and thus we just plug in upper or lower= 1 to get us what we need.

  P= power.TOST(alpha=alpha, CV=CV, 

       theta0=theta0, n=n, theta1=theta1, theta2=theta2)

  Plow= power.TOST(alpha=alpha, CV=CV, 

        theta0=theta0, n=n, theta1=theta1, theta2=1.0)  

  Phi  =power.TOST(alpha=alpha, CV=CV, 

       theta0=theta0, n=n, theta1=1.0, theta2=theta2)

  return(P-Plow-Phi)

}



pwrDK222BE(0.05, 0.3, 0.95, 0.8, 1.25, 40)

[1] 0.7652256

—
Pass or fail!
ElMaestro

Complete thread:

Denmark Curiosa (1 in 90% CI in 0.8-1.25) zizou 2017-02-05 02:03 [Power / Sample Size]
- Kudos! Helmut 2017-02-05 19:16
  - Kudos!ElMaestro 2017-02-05 21:15
    - Joking! Helmut 2017-02-06 13:27
      - Thanks, and DKMA ElMaestro 2017-02-06 13:46
        
        Power with a Danish twist Helmut 2017-02-07 15:23
        
        Danish ultra-conservatism d_labes 2017-02-08 10:57
        
        Danish ultra-conservatism Helmut 2017-02-08 11:47
    - Kudos to ElMaestro! d_labes 2017-02-06 15:06
      - Plausible Helmut 2017-02-06 17:16
        
        Plausible to me too d_labes 2017-02-06 20:25
        
        Plausible to me too ElMaestro 2017-02-06 22:30
        Plausible to me too zizou 2017-02-06 22:42
        
        THX d_labes 2017-02-07 10:01
- 3D Helmut 2017-02-06 13:47
- Denmark Curiosa (1 in 90% CI in 0.8-1.25) d_labes 2017-02-06 14:54
  - Denmark Curiosa (1 in 90% CI in 0.8-1.25) zizou 2017-02-08 21:03
    - Alternative CI for BE decision d_labes 2017-02-09 11:18
      - Alternative CI for BE decision ElMaestro 2017-02-09 11:36
        
        Alternative CI for BE decision d_labes 2017-02-09 11:48
        
        How decidedly odd ElMaestro 2017-02-09 13:28
        
        How decidedly odd zizou 2017-02-09 14:42
        
        Alternative CI for BE decision Helmut 2017-02-09 13:41
        
        No alternative d_labes 2017-02-09 20:37
        
        No alternative ElMaestro 2017-02-10 13:51
        
        No alternative? mittyri 2017-02-10 15:28
        
        Dinamarka? d_labes 2017-02-10 20:10
        
        OT: Czech beer d_labes 2017-02-10 19:57
- Denmark Curiosa (1 in 90% CI in 0.8-1.25): Gone Helmut 2019-11-08 12:47