Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log-in |  Register |  Search

Back to the forum  Query: 2017-11-24 12:56 UTC (UTC+2h)
 

Replicate designs [Design Issues]

posted by VSL - India, 2017-01-31 05:47  - Posting: # 16998
Views: 2,850

Dear All,
Could you please explain the following points?
  1. Is there any thumb rule (apart from %CV more than 30), when to use three way against four way cross over design?
  2. As we know, four way design reduces the sample size compared to three way designs, is there any additional advantage which four way design give (in terms of overall outcome of the study)?
  3. Even though variability is less than 30%, we perform three or four ways cross over study, would it enhances chance of passing the study (i.e forced BE) compared to simple two way design?
VSL
Many Thanks in advance


Edit: Subject line changed (was: Higher order cross over designs). [Helmut]

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum | Admin contact
17,495 Posts in 3,746 Threads, 1,085 registered users;
30 users online (1 registered, 29 guests).

The belief that there is only one truth and
that oneself is in possession of it,
seems to me the deepest root of all
that is evil in the world.    Max Born

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
XHTML/CSS RSS Feed