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Replicate designs [Design Issues]

posted by VSL - India, 2017-01-31 06:47  - Posting: # 16998
Views: 2,402

Dear All,
Could you please explain the following points?
  1. Is there any thumb rule (apart from %CV more than 30), when to use three way against four way cross over design?
  2. As we know, four way design reduces the sample size compared to three way designs, is there any additional advantage which four way design give (in terms of overall outcome of the study)?
  3. Even though variability is less than 30%, we perform three or four ways cross over study, would it enhances chance of passing the study (i.e forced BE) compared to simple two way design?
VSL
Many Thanks in advance


Edit: Subject line changed (was: Higher order cross over designs). [Helmut]

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