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Dear All,
Could you please explain the following points?
Many Thanks in advance
Edit: Subject line changed (was: Higher order cross over designs). [Helmut]
Could you please explain the following points?
- Is there any thumb rule (apart from %CV more than 30), when to use three way against four way cross over design?
- As we know, four way design reduces the sample size compared to three way designs, is there any additional advantage which four way design give (in terms of overall outcome of the study)?
- Even though variability is less than 30%, we perform three or four ways cross over study, would it enhances chance of passing the study (i.e forced BE) compared to simple two way design?
Many Thanks in advance
Edit: Subject line changed (was: Higher order cross over designs). [Helmut]
Complete thread:
- Replicate designsVSL 2017-01-31 06:47 [Design Issues]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Replicate designs: Pros & Cons Helmut 2017-01-31 12:42
- Replicate designs: Pros & Cons VSL 2017-01-31 14:03
- Replicate designs: Pros & Cons Balaji 2017-03-04 11:19
- Partial replicate design & ABE for the FDA Helmut 2017-03-06 11:40
- Partial replicate design & ABE for the FDA nobody 2017-03-06 13:47
- Partial replicate design & ABE for the FDA Helmut 2017-03-06 14:00
- Partial replicate design & ABE for the FDA nobody 2017-03-06 14:18
- Partial replicate design & ABE for the FDA Helmut 2017-03-06 17:49
- Partial replicate design & ABE for the FDA nobody 2017-03-06 14:18
- Partial replicate design & ABE for the FDA Helmut 2017-03-06 14:00
- Partial replicate design & ABE for the FDA nobody 2017-03-06 13:47
- Partial replicate design & ABE for the FDA Helmut 2017-03-06 11:40
- Replicate designs: Pros & Cons Helmut 2017-01-31 12:42
Ing. Helmut Schütz