Bioequivalence and Bioavailability Forum • Replicate designs

Replicate designs [Design Issues]

posted by VSL – India, 2017-01-31 07:47 (2639 d 02:43 ago) – Posting: # 16998
Views: 13,301

Dear All,
Could you please explain the following points?

Is there any thumb rule (apart from %CV more than 30), when to use three way against four way cross over design?
As we know, four way design reduces the sample size compared to three way designs, is there any additional advantage which four way design give (in terms of overall outcome of the study)?
Even though variability is less than 30%, we perform three or four ways cross over study, would it enhances chance of passing the study (i.e forced BE) compared to simple two way design?

VSL
Many Thanks in advance

Edit: Subject line changed (was: Higher order cross over designs). [Helmut]

Complete thread:

Replicate designsVSL 2017-01-31 06:47 [Design Issues]
- Replicate designs: Pros & Cons Helmut 2017-01-31 12:42
  - Replicate designs: Pros & Cons VSL 2017-01-31 14:03
  - Replicate designs: Pros & Cons Balaji 2017-03-04 11:19
    - Partial replicate design & ABE for the FDA Helmut 2017-03-06 11:40
      - Partial replicate design & ABE for the FDA nobody 2017-03-06 13:47
        
        Partial replicate design & ABE for the FDA Helmut 2017-03-06 14:00
        
        Partial replicate design & ABE for the FDA nobody 2017-03-06 14:18
        
        Partial replicate design & ABE for the FDA Helmut 2017-03-06 17:49

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