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RegisterCanada: Sample size for Cmax: R-code? [Power / Sample Size]
Hi everybody and nobody.
Or just trick without simulations with alpha setting to 0.5 (i.e. 1-2*alpha=1-2*0.5=1-1=0).
"0% confidence interval for GMR" is just GMR, I think. x)
Using exact method for power calculation with θ0 0.95, CVintra 40%, n 12, and alpha 0.5 (not 0.05) I can confirm your simulated power 82.2%.
(For θ0=0.80 with alpha=0.5 the power is around 50% as expected.)
Maybe simulations are not required here.
Best regards,
zizou
❝ ❝ Don’t agree. It’s easy enough through simulations (i.e., θ0 0.95, CVintra 40%, n 12, power 82.2%).
Or just trick without simulations with alpha setting to 0.5 (i.e. 1-2*alpha=1-2*0.5=1-1=0).
"0% confidence interval for GMR" is just GMR, I think. x)
Using exact method for power calculation with θ0 0.95, CVintra 40%, n 12, and alpha 0.5 (not 0.05) I can confirm your simulated power 82.2%.
(For θ0=0.80 with alpha=0.5 the power is around 50% as expected.)
❝ Can such a simulation be performed using PowerTOST? If no, can you please give some insight on R-code to do the task?
Maybe simulations are not required here.
Best regards,
zizou
Complete thread:
- Canada: Sample size for Cmax? Helmut 2012-12-18 18:04 [Power / Sample Size]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Canada: IUT violated? d_labes 2012-12-19 14:00
- Canada: IUT violated? Helmut 2012-12-29 15:59
- IUT d_labes 2012-12-31 13:36
- Canada: IUT violated? Helmut 2012-12-29 15:59
- Canada: Sample size for Cmax: R-code? VStus 2017-01-19 10:10
- Canada: Sample size for Cmax: R-code?zizou 2017-01-19 12:20
- HC: Sample size for AUC and Cmax: exact and sim’s Helmut 2017-01-19 12:30
- HC: Sample size for AUC and Cmax: exact and sim’s VStus 2017-01-31 13:44
- Canada: IUT violated? d_labes 2012-12-19 14:00
Ing. Helmut Schütz